Abstract

Inadequate vitamin D levels and vitamin D variants have been shown to be associated with breast cancer (BC), however the results are inconsistent. To reach a definitive conclusion the present meta-analysis was conducted. When compared to healthy controls, BC patients had reduced vitamin D levels (standard difference in means = −0.564, p = 0.003). The meta-analysis revealed that the FokI mutation was linked with an increased BC susceptibility (CC vs. TT: OR = 1.107, p = 0.001, CC vs. TC + TT: OR = 1.114, p = 0.020). There was no role of other VDR variants (BsmI, TaqI, and ApaI). FokI mutation and diminished vitamin D increase the likelihood of developing BC.

摘要

维生素 D 水平不足和维生素 D 变体已被证明与乳腺癌 (BC) 相关，但结果并不一致。为了得出明确的结论，进行了本荟萃分析。与健康对照组相比，BC 患者的维生素 D 水平降低（平均值的标准差 = -0.564，p  = 0.003）。荟萃分析显示FokI突变与 BC 易感性增加有关（CC 与 TT：OR  = 1.107，p  = 0.001，CC 与 TC + TT：OR  = 1.114，p  = 0.020）。没有其他 VDR 变体（BsmI、TaqI和ApaI）的作用。福克突变和维生素 D 减少会增加患 BC 的可能性。