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Navigating ferroptosis via an NADPH sensor
Nature Cell Biology ( IF 17.3 ) Pub Date : 2022-08-08 , DOI: 10.1038/s41556-022-00963-3
Chao Mao 1 , Boyi Gan 1, 2
Affiliation  

NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and modulate downstream ferroptosis responses are unknown. A study now identifies MARCHF6 in the ubiquitin system as an NADPH sensor that suppresses ferroptosis.

中文翻译:


通过 NADPH 传感器应对铁死亡



NADPH 水平可作为铁死亡敏感性的生物标志物,但检测细胞 NADPH 水平并调节下游铁死亡反应的调节因子尚不清楚。一项研究现已确定泛素系统中的 MARCHF6 是一种抑制铁死亡的 NADPH 传感器。
更新日期:2022-08-09
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