Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.

中文翻译：

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肿瘤治疗电场的作用机制

肿瘤治疗场（TTFields）是一种新的癌症治疗方式，是透皮传输至肿瘤的电场。FDA 已批准 TTFields 用于治疗多形性胶质母细胞瘤和间皮瘤，目前正在对许多其他癌症类型进行研究。虽然抗有丝分裂作用是 TTFields 第一个被认可的生物抗癌活性，但数据表明，肿瘤治疗领域通过多种作用机制实现其抗癌作用。因此，TTFields 能够与许多不同的治疗方式相结合，对许多癌症类型有用。在这里，我们回顾一下目前对 TTFields 及其作用机制的理解。