A novel screen-printed electrode (SPE) for potentiometric determination of nalbuphine (NAL) is described. Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane incorporated with molecularly imprinted drug polymer (MIP) beads as a recognition receptor for potentiometric determination a synthetic narcotic, nalbuphine (NAL). The SPE displays a Nernstian response with a slope of 60.3 ± 1.2 mV/decade (R² = 0.999) over the concentration range 2.4 × 10⁻⁷ – 5.0 × 10⁻² mol/L and a detection limit of 1.1 × 10⁻⁷ mol/L (0.04 μg/mL) with response time less than 20 s (<20 s). The interfacial capacitance of the proposed SPE is measured using chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). The use of the f-MWCNTs/PANI nanocomposite layer improved the interfacial capacitance reached 52.5 μF. Besides, it eliminated the formation of the undesired thin water-layer between the sensing membrane and the conducting substrate. This prevents membrane delamination and increases potential stability. The obtained high selectivity, sensitivity and potential stability offered a great applicability of the proposed SPE for the determination of nalbuphine in hospitals for rapid diagnosis of overdose patients and for quality control/quality assurance in pharmaceutical industry.

介绍了一种用于电位测定纳布啡 (NAL) 的新型丝网印刷电极 (SPE)。羧化多壁碳纳米管/聚苯胺 ( f -MWCNTs/PANI) 纳米复合材料用作离子电子转换器，并覆盖有选择性聚氯乙烯 (PVC) 膜，并结合有分子印迹药物聚合物 (MIP) 珠作为用于电位测定的识别受体 合成麻醉剂纳布啡 (NAL)。^{SPE 在 2.4 × 10 -7} – 5.0 × 10 ^-2 mol/L 的浓度范围和 1.1 × 10 ^-7 的检测限内显示能斯特响应，斜率为 60.3 ± 1.2 mV/decade (R ^{2 = 0.999)} mol/L (0.04 μg/mL)，响应时间小于 20 s (<20 s)。所提出的 SPE 的界面电容是使用计时电位法 (CP) 和电化学阻抗谱 (EIS) 测量的。使用f- MWCNTs/PANI 纳米复合材料层将界面电容提高到 52.5 μF。此外，它消除了传感膜和导电基板之间不希望的薄水层的形成。这可以防止膜分层并提高电位稳定性。所获得的高选择性、灵敏度和潜在稳定性为所提出的 SPE 在医院中测定纳布啡以快速诊断过量患者和制药行业的质量控制/质量保证提供了很大的适用性。