Metal-organic cages (MOCs), as a promising class of crystalline porous materials with well-defined cavities, have attracted wide attention due to their multifarious potential applications in gas storage, host-guest chemistry, molecular recognition, separation, catalysis, sensing, and drug delivery and so on. Herein, we report that a chiral MOC [Fe₄L₆](ClO₄)₈ coated capillary column was fabricated for high-resolution gas chromatographic separation of various analytes, including n-alkanes, n-alcohols, positional isomers, aromatic hydrocarbon mixture, especially for racemic compounds. A series of racemic compounds such as alcohols, epoxides, aldehydes, ketones, ethers, esters, alkenes, sulfoxides and amino acid derivatives could be well separated on the [Fe₄L₆](ClO₄)₈ coated capillary column with high enantioselectivity and good reproducibility. Comparing the chiral resolution ability of the MOC [Fe₄L₆](ClO₄)₈ coated column with the commercial β-DEX 120 column and the porous organic cage (POC) CC10 coated column, the chiral MOC column can be complementary to the two different types of columns. The results show that the chiral MOC [Fe₄L₆](ClO₄)₈ exhibited excellent separation performance toward a wide range of organic compounds, which will be very attractive as a new chiral separation media and has potential application prospects in separation science.

金属有机笼（MOCs）作为一类有前途的具有明确空腔的结晶多孔材料，由于其在储气、主客体化学、分子识别、分离、催化、传感、以及药物输送等。在此，我们报道了手性 MOC [Fe ₄ L ₆ ](ClO ₄ ) ₈涂层毛细管柱用于对各种分析物进行高分辨率气相色谱分离，包括正构烷烃、正醇、位置异构体、芳烃混合物，特别是外消旋化合物。[Fe ₄ L ₆ ](ClO ₄ ) ₈涂层毛细管柱具有高对映选择性和重现性好。比较 MOC [Fe ₄ L ₆ ](ClO ₄ ) _{8的手性拆分能力}涂层色谱柱与市售的 β-DEX 120 色谱柱和多孔有机笼 (POC) CC10 涂层色谱柱相结合，手性 MOC 色谱柱可以与两种不同类型的色谱柱互补。结果表明，手性MOC [Fe ₄ L ₆ ](ClO ₄ ) ₈对多种有机化合物均表现出优异的分离性能，作为一种新型手性分离介质将极具吸引力，在分离科学中具有潜在的应用前景。