Metastasis, the major cause of cancer death, represents one of the major challenges in oncology. Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy, and how they interact with their new microenvironment. We asked experts to discuss some of the unknowns, advances, and areas of opportunity related to cancer metastasis.

中文翻译：

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转移

转移是癌症死亡的主要原因，是肿瘤学的主要挑战之一。科学家们仍在努力了解肿瘤细胞传播和生长的生物学基础，为什么这些细胞可以保持休眠多年，它们如何对免疫系统或全身治疗的细胞毒性作用产生抵抗力，以及它们如何与新的微环境相互作用. 我们请专家讨论了与癌症转移相关的一些未知数、进展和机会领域。