Morphology, immunophenotype, cytogenetics, and genomics have long dominated diagnostics in acute myelogenous leukemia (AML). In this issue of Cancer Cell, Bottomly et al. demonstrate that combining the above with transcriptomics and ex vivo drug testing of patient myeloblasts yields novel diagnostic and therapeutic insights with the potential for clinical translation.

中文翻译：

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AML 中的精准医学：功能加组学优于单独组学

形态学、免疫表型、细胞遗传学和基因组学长期以来一直主导着急性髓性白血病 (AML) 的诊断。在本期《癌细胞》中，Bottomly 等人。证明将上述与患者成髓细胞的转录组学和离体药物测试相结合，产生了具有临床转化潜力的新诊断和治疗见解。