PURPOSE

To evaluate whether frequent vigorous physical activity (PA) is significantly associated with active central serous chorioretinopathy (CSCR) and may represent a risk factor for CSCR.

DESIGN

Case-control study.

METHODS

This was a multicenter study. The patient population comprised consecutive patients with active CSCR and a comparable control group of healthy participants. Both groups were interrogated about their PA using a shortened version of the International Physical Activity Questionnaire. The Ainsworth Compendium of Physical Activities was taken as a reference for the activities requiring vigorous effort and to quantify the energy expended, expressed in metabolic equivalent of task (MET). As a main outcome measure, a moderate/high practice of vigorous PA was opposed to an absent/low practice of vigorous PA in the 2 groups.

RESULTS

A total of 105 patients with CSCR and 105 healthy controls were included in the study. Moderate/high vigorous PA was observed in 63.5% of the patients with CSCR and in 26% of the controls (P = .0001). The MET values of vigorous PA were 2173.2 ± 2081.5 in the CSCR group and 1216.3 ± 524 in the control group (P = .029). The potential risk of disease associated with moderate/high vigorous PA was 5.58 (odds ratio; 95% confidence interval 3.01-10.69, P = .0001).

CONCLUSIONS

This study demonstrates a significant association of vigorous PA with CSCR, indicating an increased probability of disease by 5.58 times. Frequent and intense PA, with the hypertensive episodes that it entails, can break the precarious hemodynamic balance in the choroid of individuals predisposed to CSCR, thereby favoring choroidal vascular decompensation and active disease.

中文翻译：

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剧烈运动是中枢性浆液性脉络膜视网膜病变的危险因素

目的

评估频繁的剧烈体力活动 (PA) 是否与活动性中心性浆液性脉络膜视网膜病变 (CSCR) 显着相关，并可能代表 CSCR 的危险因素。

设计

病例对照研究。

方法

这是一项多中心研究。患者人群包括连续的具有活动 CSCR 的患者和相当的健康参与者对照组。使用简化版的国际身体活动问卷询问两组的 PA。Ainsworth Compendium of Physical Activities 被用作需要剧烈努力的活动的参考，并量化消耗的能量，以任务的代谢当量 (MET) 表示。作为主要结果衡量指标，两组中中度/高强度 PA 练习与缺乏/低强度 PA 练习相反。

结果

该研究共纳入 105 名 CSCR 患者和 105 名健康对照者。在 63.5% 的 CSCR 患者和 26% 的对照组中观察到中度/高强度 PA ( P  = .0001)。CSCR 组中剧烈 PA 的 MET 值为 2173.2 ± 2081.5，对照组为 1216.3 ± 524 ( P  = .029)。与中度/高强度 PA 相关的潜在疾病风险为 5.58（比值比；95% 置信区间 3.01-10.69，P  = .0001）。

结论

这项研究表明，充满活力的 PA 与 CSCR 有显着关联，表明疾病概率增加了 5.58 倍。频繁和强烈的 PA 及其引起的高血压发作，可以打破易患 CSCR 的个体脉络膜中不稳定的血流动力学平衡，从而有利于脉络膜血管失代偿和活动性疾病。