Background

Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world. A similar phenomenon is identified in psychopathology and is associated with the balance of anticorrelated activity between the default mode network, which directs attention inward, and the salience network, which recruits the dorsal attention network to direct attention outward.

Methods

To test whether changes in anticorrelated networks underlie the peak effects of lysergic acid diethylamide (LSD), we applied dynamic causal modeling to infer effective connectivity of resting-state functional magnetic resonance imaging scans from a study of 25 healthy adults who were administered 100 μg of LSD or placebo.

Results

We found that inhibitory effective connectivity from the salience network to the default mode network became excitatory, and inhibitory effective connectivity from the default mode network to the dorsal attention network decreased under the peak effect of LSD.

Conclusions

The effective connectivity changes we identified may reflect diminution of the functional anticorrelation between resting-state networks that may be a key neural mechanism of LSD and underlie ego dissolution. Our findings suggest that changes to the sense of self and subject-object boundaries across different states of consciousness may depend upon the organized balance of effective connectivity of resting-state networks.

中文翻译：

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麦角酸二乙胺作用下功能反相关网络的有效连通性

背景

经典迷幻药引起的自我消解涉及自我意识的转变以及自我与世界之间界限的模糊。在精神病理学中发现了类似的现象，并且与将注意力向内引导的默认模式网络和招募背侧注意网络以将注意力向外引导的显着网络之间的反相关活动的平衡有关。

方法

为了测试反相关网络的变化是否是麦角酸二乙胺 (LSD) 峰值效应的基础，我们应用动态因果模型来推断静息态功能磁共振成像扫描的有效连通性，该扫描来自一项对 25 名健康成年人的研究，这些成年人服用了 100 μg LSD 或安慰剂。

结果

我们发现在 LSD 的峰值效应下，从显着网络到默认模式网络的抑制性有效连接变得兴奋，并且从默认模式网络到背侧注意网络的抑制性有效连接减少。

结论

我们确定的有效连通性变化可能反映了静息态网络之间功能反相关的减少，这可能是 LSD 的关键神经机制，也是自我消解的基础。我们的研究结果表明，不同意识状态下自我意识和主客体边界的变化可能取决于静息态网络有效连接的有组织平衡。