Sequential evaluation of MUC promoter methylation using next-generation sequencing-based custom-made panels in liquid-based cytology specimens of pancreatic cancer,Diagnostic Cytopathology

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Sequential evaluation of MUC promoter methylation using next-generation sequencing-based custom-made panels in liquid-based cytology specimens of pancreatic cancer
Diagnostic Cytopathology ( IF 1.0 ) Pub Date : 2022-08-04 , DOI: 10.1002/dc.25022
Sieya Yokoyama ₁ , Hiromichi Iwaya ₂ , Toshiaki Akahane _{1,

3} , Taiji Hamada ₁ , Michiyo Higashi ₄ , Shinichi Hashimoto ₂ , Shiroh Tanoue ₂ , Takao Ohtsuka ₅ , Akio Ido ₂ , Akihide Tanimoto _{1,

3,

4}

Affiliation

As liquid-based cytology (LBC) specimens preserve high-quality DNA, clinical sequencing of LBC specimens using next-generation sequencing (NGS) is becoming a common strategy. This study aimed to evaluate the feasibility of NGS-based custom-made panels for evaluating MUC promoter methylation in LBC specimens.

中文翻译：

使用基于下一代测序的定制面板对胰腺癌液基细胞学标本中的 MUC 启动子甲基化进行顺序评估

由于液基细胞学 (LBC) 标本保留了高质量的 DNA，因此使用下一代测序 (NGS) 对 LBC 标本进行临床测序正在成为一种常见策略。本研究旨在评估基于 NGS 的定制面板用于评估 LBC 样本中MUC启动子甲基化的可行性。

更新日期：2022-08-04

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