Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease,Movement Disorders

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Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease
Movement Disorders ( IF 7.4 ) Pub Date : 2022-08-03 , DOI: 10.1002/mds.29157
Xuelin Tang ₁ , Paulina Gonzalez-Latapi _{2,

3} , Connie Marras _{2,

4} , Naomi P Visanji _{2,

5,

6,

7} , Wanli Yang ₁ , Christine Sato ₅ , Anthony E Lang _{2,

4,

7} , Ekaterina Rogaeva _{4,

5} , Ming Zhang _{1,

8,

9}

Affiliation

Aging is the strongest risk factor for Parkinson's disease (PD), which is a clinically heterogeneous movement disorder with highly variable age at onset. DNA methylation age (DNAm age) is an epigenetic clock that could reflect biological aging.

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