Palladium-catalyzed native α-amino acid derivative-directed arylation/oxidation of benzylic C–H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones,Chemical Communications

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Palladium-catalyzed native α-amino acid derivative-directed arylation/oxidation of benzylic C–H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-08 , DOI: 10.1039/d2cc03266j
Fengxuan Jiang _{1,

2} , Menghua Xu ₃ , Wenfeng Bei ₁ , Kai Cheng ₁ , Lehao Huang ₂

Affiliation

A Pd-catalyzed, native α-amino acid derivative-directed benzylic C–H bond arylation/oxidation with aryl iodides was developed. The natural amino acid auxiliary could serve as a desired building block for formation of 5-aryl-1,4-benzodiazepin-2-ones after removal of the trifluoroacetyl protecting group. The bifunctional reaction probably proceeded through a sequential benzylic arylation/oxidation process.

中文翻译：

钯催化的天然 α-氨基酸衍生物定向芳基化/苄基 C-H 键的氧化：5-aryl-1,4-benzodiazepin-2-ones 的合成

开发了一种 Pd 催化的、天然 α-氨基酸衍生物导向的苄基 C-H 键芳基化/芳基碘化物氧化。在去除三氟乙酰基保护基团后，天然氨基酸助剂可用作形成 5-aryl-1,4-benzodiazepin-2-ones 的所需结构单元。双功能反应可能通过连续的苄基芳基化/氧化过程进行。

更新日期：2022-08-08

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