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UHPLC‐Q‐TOF‐MS/MS Dereplication to Identify Chemical Constituents of Hedera helix Leaves in Vietnam
Journal of Analytical Methods in Chemistry ( IF 2.3 ) Pub Date : 2022-08-08 , DOI: 10.1155/2022/1167265
Hong Ngoc Pham 1 , Chieu An Tran 1 , Thi Diep Trinh 2 , Ngoc Lan Nguyen Thi 3 , Huynh Nhu Tran Phan 1 , Van Nhan Le 1 , Ngoc Hung Le 1 , Van Trung Phung 1
Affiliation  

Hedera helix has been reported to contain a wide range of metabolites and produce many pharmacological effects. This research demonstrates the determination and evaluation of the phytochemical profiling of H. helix grown in central Vietnam. Methanolic extract of ivy had been analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC‐Q‐TOF‐MS/MS). MS, and MS/MS experiments were manipulated using both negative and positive ionization modes to provide molecular mass information and production spectra for the structural elucidation of compounds. A total of 46 compounds including 24 triterpene saponins and other compounds were successfully identified of which four established saponin structures have been reported for the first time. This study has provided a base for building a quality control of the raw materials according to the profile of triterpene saponins and assessment of pharmaceutical ingredients of H. helix planted in Vietnam.

中文翻译:

UHPLC-Q-TOF-MS/MS 去复制鉴定越南常春藤叶的化学成分

据报道,常春藤含有多种代谢物并产生许多药理作用。这项研究展示了H. helix的植物化学分析的测定和评估生长于越南中部。通过超高效液相色谱-四极杆飞行时间质谱 (UHPLC-Q-TOF-MS/MS) 分析了常春藤的甲醇提取物。MS 和 MS/MS 实验使用负电离和正电离模式进行操作,以提供用于化合物结构解析的分子质量信息和生产光谱。共成功鉴定出46个化合物,包括24个三萜皂苷等化合物,其中4个已建立的皂苷结构为首次报道。该研究为根据三萜皂苷的概况和越南种植的螺旋藻药物成分的评估建立原材料的质量控制提供了基础。
更新日期:2022-08-08
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