Cognitive resilience depends on white matter connectivity: The Maastricht Study,Alzheimer's & Dementia

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Cognitive resilience depends on white matter connectivity: The Maastricht Study
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-08-03 , DOI: 10.1002/alz.12758
Nathan R DeJong _{1,

2,

3,

4} , Jacobus F A Jansen _{1,

4,

5} , Martin P J van Boxtel _{1,

3,

4} , Miranda T Schram _{1,

6,

7,

8} , Coen D A Stehouwer _{6,

7} , Pieter C Dagnelie _{6,

7} , Carla J H van der Kallen _{6,

7} , Abraham A Kroon _{6,

7} , Anke Wesselius ₉ , Annemarie Koster _{10,

11} , Walter H Backes _{1,

4,

5} , Sebastian Köhler _{1,

2,

3}

Affiliation

School for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Alzheimer Centrum Limburg, Maastricht University Medical Center+, Maastricht, The Netherlands.
Department of Radiology & Nuclear Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
School for Cardiovascular Diseases (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Maastricht Heart & Vascular Center, Maastricht University Medical Center+, Maastricht, The Netherlands.
School of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Department of Social Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle-aged individuals.

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