Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibrillary tangle maturity levels (pretangle, intermediary 1, mature tangle, intermediary 2, and ghost tangle) are recognized.

中文翻译：

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阿尔茨海默病液体生物标志物中磷酸化的 tau 位点在死后大脑的早期神经原纤维缠结成熟度水平中可见


阿尔茨海默病 (AD) 生物标志物在预测神经病理学方面越来越可靠。为了便于将磷酸化 tau 位点解释为早期液体生物标志物，我们试图表征哪些神经原纤维缠结成熟度水平（前缠结、中间 1、成熟缠结、中间 2 和鬼缠结）被识别。