A Multicenter, Prospective, Randomized, Parallel-Group Trial on the Effects of Temporary Methotrexate Discontinuation for One Week Versus Two Weeks on Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis,Arthritis & Rheumatology

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A Multicenter, Prospective, Randomized, Parallel-Group Trial on the Effects of Temporary Methotrexate Discontinuation for One Week Versus Two Weeks on Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-08-05 , DOI: 10.1002/art.42318
Jin Kyun Park ₁ , Yun Jong Lee ₂ , Kichul Shin ₃ , Eun Ha Kang ₄ , You-Jung Ha ₄ , Jun Won Park ₅ , Min Jung Kim ₃ , Mi Hyeon Kim ₅ , Se Rim Choi ₅ , Youjin Jung ₅ , Ju Ho Lee ₄ , Ji In Jung ₅ , Ju Yeon Kim ₅ , Kevin L Winthrop ₆ , Eun Bong Lee ₇

Affiliation

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, and Seoul National University Hospital, Seoul, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, and Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Division of Infectious Diseases, Oregon Health and Science University, Portland.
Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea, and Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.

This clinical trial was conducted to investigate whether discontinuing methotrexate (MTX) for 1 week after seasonal influenza vaccination is noninferior to discontinuing for 2 weeks after vaccination in patients with rheumatoid arthritis (RA).

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