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Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-07-31 , DOI: 10.1002/art.42321
Maria Prendecki 1 , Kavita Gulati 1 , Noelle Pisacano 2 , Damilola Pinheiro 3 , Tejal Bhatt 3 , Marie-Anne Mawhin 3 , Frederic Toulza 3 , Esteban S Masuda 4 , Andrew Cowburn 2 , Katharine M Lodge 2 , Frederick W K Tam 1 , Candice Roufosse 3 , Charles D Pusey 1 , Stephen P McAdoo 1
Affiliation  

Syk is a cytoplasmic protein tyrosine kinase that plays a role in signaling via B cell and Fc receptors (FcR). FcR engagement and signaling via Syk is thought to be important in antineutrophil cytoplasm antibody (ANCA) IgG–mediated neutrophil activation. This study was undertaken to investigate the role of Syk in ANCA-induced myeloid cell activation and vasculitis pathogenesis.

中文翻译:

抗中性粒细胞胞浆抗体相关性血管炎循环和组织先天免疫细胞中的 Syk 激活

Syk 是一种细胞质蛋白酪氨酸激酶,通过 B 细胞和 Fc 受体 (FcR) 在信号传导中发挥作用。FcR 参与和通过 Syk 的信号被认为在抗中性粒细胞胞质抗体 (ANCA) IgG 介导的中性粒细胞激活中很重要。本研究旨在调查 Syk 在 ANCA 诱导的骨髓细胞活化和血管炎发病机制中的作用。
更新日期:2022-07-31
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