Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis,Journal of Cachexia, Sarcopenia and Muscle

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Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2022-08-04 , DOI: 10.1002/jcsm.13050
Jan Spaas _{1,

2,

3} , Richie P Goulding ₄ , Charly Keytsman _{1,

2} , Lena Fonteyn _{1,

2} , Jack van Horssen _{1,

5} , Richard T Jaspers ₄ , Bert O Eijnde _{1,

2} , Rob C I Wüst ₄

Affiliation

Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and peripheral muscle in MS-induced exercise intolerance before and after exercise training.

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