We have read with the outmost interest the recent publication by Dayer SR et al¹ entitled “Does Superior Bone Health Promote a Longer Lifespan?” which paves the path of a direct implication of bone health on longevity. This paper was then followed by an intriguing letter to the Editor by Nguyen VH² entitled “Superior Bone Health for Promoting Longer and Better Lives” which invoked for a wider understanding of such situation, requiring for life quality to be added to the mixture as another positive influence of superior bone health. We concur in both cases with the authors, strongly believing that the quality of life is not just equally important with the longevity, but it is undoubtedly also interrelated to it. However, the “superior bone health” presents a state that prevailed notwithstanding the external/internal opposing forces (ie disease). In this context we would like to try headhunting for the “bad guys” that might be responsible to the situation and that we feel are often misunderstood and misinterpreted. Amongst others, osteosarcopenia presents a novel concept which intends to describe the coexistence of both osteoporosis/osteopenia (lower bone mineral density) and sarcopenia (lower muscle mass and function (strength and/or performance)) within the same person. It has already been described as a serious risk factor for both mortality and morbidity.³ Having in mind the consequences of osteoporosis/osteopenia and sarcopenia on bone and muscle independently but also interchangeably through the functional muscle-bone unit,⁴ it should be amongst the top priority obstacles on the path to a greater lifespan, always not undermining the potential share of genetic and other environmental influences on the matter.

中文翻译：

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骨骼/肌肉相互作用作为寿命和质量的良好生物标志物

我们怀着极大的兴趣阅读了 Dayer SR 等人最近发表的题为“优质骨骼健康能延长寿命吗？”的文章^{1 。}这为骨骼健康对长寿的直接影响铺平了道路。^{这篇论文之后是 Nguyen VH 2}给编辑的一封有趣的信题为“促进更长寿和更好的生活的优质骨骼健康”，呼吁更广泛地了解这种情况，要求将生活质量添加到混合物中，作为优质骨骼健康的另一个积极影响。我们在这两种情况下都同意作者的观点，坚信生活质量不仅与长寿同等重要，而且毫无疑问也与之相关。然而，“卓越的骨骼健康”呈现出一种尽管存在外部/内部对立力量（即疾病）的状态。在这种情况下，我们想尝试寻找可能对这种情况负责并且我们认为经常被误解和误解的“坏人”。在其他人中，骨肌肉减少症提出了一个新概念，旨在描述同一个人体内同时存在骨质疏松症/骨质减少症（较低的骨矿物质密度）和肌肉减少症（较低的肌肉质量和功能（强度和/或表现））。它已被描述为死亡率和发病率的严重风险因素。³考虑到骨质疏松症/骨质减少和肌肉减少症对骨骼和肌肉的影响，但也可以通过功能性肌肉-骨骼单元互换，⁴它应该是通往更长寿命道路上的首要障碍之一，始终不破坏潜力遗传和其他环境影响对此事的影响。