r further investigation. Although the scientific community initially resisted Dr Albright’s idea, his editorial would ultimately lead to several important advancements in anesthesiology. In 1983, the US Food and Drug Administration issued a black box warning that recommended against the use of 0.75% bupivacaine in obstetric anesthesia. This warning would remain in place until 1999. In addition, Dr Albright’s article led to the following changes: laboratory research that proved the cardiotoxicity of bupivacaine; the development of safer, stereoselective agents like ropivacaine; and the acceptance of lipid emulsion as a treatment for local anesthetic toxicity. In this article, C. Philip Larson, Jr, MDCM, Editor-in-Chief of Anesthesiology at the time of publication of Albright’s manuscript, provides a unique perspective on the bupivacaine story....

中文翻译：

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布比卡因的故事：向医学博士乔治·A·奥尔布赖特 (1931–2020) 致敬

进一步调查。尽管科学界最初反对奥尔布赖特博士的想法，但他的社论最终导致了麻醉学的几项重要进步。1983年，美国食品药品监督管理局发布黑框警告，建议不要在产科麻醉中使用0.75%的布比卡因。这一警告一直持续到 1999 年。此外，奥尔布赖特博士的文章导致了以下变化：证明布比卡因心脏毒性的实验室研究；开发更安全的立体选择性药物，如罗哌卡因；接受脂肪乳剂作为治疗局部麻醉剂中毒的方法。在这篇文章中，奥尔布赖特手稿出版时麻醉学主编 C. Philip Larson, Jr, MDCM 对布比卡因的故事提供了独特的视角……