ited patients undergoing primary unilateral THR under general anesthesia (GA) who received either single-shot ESPB at L1 (treatment arm) or no block (control arm). Patients were followed up on the first day postoperatively. We hypothesized that compared to no block, a single-shot lumbar ESPB at L1 would reduce postoperative fentanyl use and postoperative pain scores. Primary outcomes were intravenous fentanyl use at 12 and 24 hours postoperatively, along with pain intensity in numeric rating scale (0–10) at rest and upon movement on the first day postoperatively. Per-protocol analysis was performed. Mann-Whitney U test was used to compare the outcomes between both groups, and median difference was derived from the Hodges-Lehmann estimator. RESULTS: Seventy-one patients were randomized (n = 36 in treatment arm, n = 35 in control arm). The median amount of fentanyl consumed at 12 hours postoperatively was 210 (quartiles, 140.5–363) μg for the ESPB group and 165 (quartiles, 77.5–330.5) μg for the control group, while at 24 hours postoperatively, it was 409 (quartiles, 221–636.5) μg for the former and 349 (quartiles, 114–626.5) μg for the latter. The median differences in fentanyl consumption 12 and 24 hours postoperatively were 39 μg (95% confidence interval [CI], −40 to 116; P = .463) and 41 μg, respectively (95% CI, −83.5 to 199.5; P = .474), which were statistically insignificant. The median pain score at rest was 3 for both the ESPB group (quartiles, 0–5) and the control group (quartiles, 0–4.5), while upon movement, it was 7 for both the former (quartiles, 6–8) and the latter (quartiles, 4.5–8.5). The median difference in pain scores between both groups was 0 at rest (95% CI, −1 to 1; P = .890) and upon movement (95% CI, −1 to 1; P = .509). CONCLUSIONS: This trial did not demonstrate that ESPB at L1 improved analgesia following THR....

中文翻译：

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全髋关节置换术中的单次腰椎竖脊肌平面阻滞：一项随机临床试验

在全身麻醉 (GA) 下接受原发性单侧 THR 的患者在 L1 接受单次 ESPB（治疗组）或无阻滞（控制组）。术后第一天对患者进行随访。我们假设与无阻滞相比，L1 的单次腰椎 ESPB 会降低术后芬太尼的使用和术后疼痛评分。主要结局是术后 12 小时和 24 小时静脉使用芬太尼，以及术后第一天休息时和运动时的疼痛强度（0-10）。进行了符合方案分析。Mann-Whitney U检验用于比较两组之间的结果，中位数差异来自Hodges-Lehmann估计量。结果：71 名患者被随机分组​​（治疗组 n = 36，对照组 n = 35）。ESPB 组在术后 12 小时消耗的芬太尼中位数为 210（四分位数，140.5-363）μg，对照组为 165（四分位数，77.5-330.5）μg，而术后 24 小时为 409（四分位数） ，前者为 221–636.5) μg，后者为 349（四分位数，114–626.5) μg。术后 12 小时和 24 小时芬太尼用量的中位数差异分别为 39 μg（95% 置信区间 [CI]，-40 至 116；P = .463）和 41 μg（95% CI，-83.5 至 199.5；P = .474），在统计上不显着。ESPB 组（四分位数，0-5）和对照组（四分位数，0-4.5）的休息时疼痛评分中位数为 3，而运动时，前者（四分位数，6-8）均为 7和后者（四分位数，4.5-8.5）。两组之间疼痛评分的中位数差异在休息时（95% CI，-1 至 1；P = .890）和运动时（95% CI，-1 至 1；P = .509）为 0。结论：该试验并未证明 L1 的 ESPB 改善了 THR 后的镇痛效果......