Introduction: The prevalence and patterns of sleep disturbances in neurocutaneous syndromes are variable and understudied. Methods: Cross-sectional study for 18 months at a tertiary care pediatric hospital, involving 100 children with neurocutaneous syndromes aged between 4 and 10 years using the Children's Sleep Habits Questionnaire-Abbreviated. Results: In 100 children with neurocutaneous syndromes, 47 (47%) had significant sleep problems. In subgroup analysis, 7 of 17 children with neurofibromatosis 1, 24 of 63 children with tuberous sclerosis complex, 10 of 12 children with Sturge-Weber syndrome, 2 of 3 children with linear nevus sebaceous syndrome, and each of the children with hypomelanosis of Ito, McCune-Albright syndrome, megalencephaly-capillary malformation syndrome, and unclassified neurocutaneous syndrome had significant sleep problems. Conclusion: The prevalence of sleep problems in our study population was not more than that observed in the general pediatric population. Prospective multicentric studies are needed to comprehend sleep problems in children with neurocutaneous syndromes.

简介：神经皮肤综合征中睡眠障碍的患病率和模式是多变的，并且研​​究不足。方法：在一家三级儿科医院进行为期 18 个月的横断面研究，涉及 100 名 4 至 10 岁的神经皮肤综合征儿童，使用儿童睡眠习惯问卷-缩写。结果：在 100 名患有神经皮肤综合征的儿童中，47 名 (47%) 有严重的睡眠问题。在亚组分析中，17 名儿童中有 7 名患有神经纤维瘤病 1、63 名儿童中有 24 名患有结节性硬化症、12 名儿童中有 10 名患有 Sturge-Weber 综合征、3 名儿童中有 2 名患有线性痣皮脂腺综合征，以及每名患有 Ito 色素减退症的儿童、McCune-Albright 综合征、巨脑畸形-毛细血管畸形综合征和未分类的神经皮肤综合征有明显的睡眠问题。结论：在我们的研究人群中，睡眠问题的发生率并不高于在一般儿科人群中观察到的情况。需要前瞻性的多中心研究来了解神经皮肤综合征儿童的睡眠问题。