PMT is a protein toxin produced by Pasteurella multocida serotypes A and D. As causative agent of atrophic rhinitis in swine, it leads to rapid degradation of the nasal turbinate bone. The toxin acts as a deamidase to modify a crucial glutamine in heterotrimeric G proteins, which results in constitutive activation of the G proteins and permanent stimulation of numerous downstream signaling pathways.

中文翻译：

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多杀巴氏杆菌毒素 (PMT) 结合蛋白的全基因组 CRISPR 筛选显示 LDL 受体相关蛋白 1 (LRP1) 是关键的细胞受体

PMT 是由多杀性巴氏杆菌A 型和 D 型产生的一种蛋白质毒素。作为猪萎缩性鼻炎的病原体，它会导致鼻甲骨快速降解。该毒素充当脱酰胺酶来修饰异源三聚体 G 蛋白中的关键谷氨酰胺，从而导致 G 蛋白的组成型激活和许多下游信号通路的永久刺激。