Per-/Poly- fluoroalkyl substances represent emerging persistent organic pollutants. Their toxic effects can be broad, yet little attention has been given to organisms at the microscale. To address this knowledge shortfall, the unicellular eukaryote Tetrahymena pyriformis was exposed to increasing concentrations (0–5000 μM) of PFOA/PFOS and monitored for cellular motility, division and function (i.e., phagocytosis), reactive oxygen species generation and total protein levels. Both PFOA/PFOS exposure had negative impacts on T. pyriformis, including reduced motility, delayed cell division and oxidative imbalance, with each chemical having distinct toxicological profiles. T. pyriformis represents a promising candidate for assessing the biological effects these emerging anthropogenically-derived contaminants in a freshwater setting.

全/多氟烷基物质代表新兴的持久性有机污染物。它们的毒性作用可能很广泛，但对微观生物的关注却很少。为了解决这一知识不足，单细胞真核生物梨形四膜虫暴露于浓度增加（0-5000 μM）的 PFOA/PFOS 中，并监测细胞运动、分裂和功能（即吞噬作用）、活性氧的产生和总蛋白水平。PFOA/PFOS 暴露对梨形锥虫都有负面影响，包括运动性降低、细胞分裂延迟和氧化失衡，每种化学物质都有不同的毒理学特征。T. pyriformis代表了评估淡水环境中这些新兴的人为衍生污染物的生物效应的有希望的候选者。