Following operative treatment of chondrosarcoma, post-surgery tissue reconstruction may be confronted with daunting challenges, including the delayed self-repair of defective tissue, tumor recurrence, and bacterial infection. To overcome these challenges, a methacrylic anhydride (MA) modified sericin (SerMA) solution mixed with procyanidins (PC) loaded polydopamine (PDA) modified ZIF-8 (PC@ZIF-8@PDA) nanoparticles to form a multifunctional PC@ZIF-8@PDA/SerMA hydrogel after exposure under blue light. Hydrogel products with pre-designed shapes were printed out by using the SerMA solution carrying PC@ZIF-8@PDA nanoparticles and chondrocytes, indicating that PC@ZIF-8@PDA/SerMA hydrogels with personalized shapes can be fabricated via 3D printing. Photocrosslinked PC@ZIF-8@PDA/SerMA hydrogel is able to kill chondrosarcoma cells and bacteria, like Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli), by its photothermal activity combined with near-infrared radiation (NIR). The PC@ZIF-8@PDA/SerMA hydrogel exhibited an antioxidative activity and a good biocompatibility and was easily monitored by its florescent and photoacoustic properties. Rabbit articular cartilage defects were efficiently repaired by PC@ZIF-8@PDA/SerMA hydrogels with encapsulated corresponding autologous chondrocytes, and mice skin burning wounds were swiftly regenerated by applying this hydrogel. Hence, the PC@ZIF-8@PDA/SerMA hydrogel can be potentially applied to the clinic treatment of chondrosarcoma and tissue defect repair after chondrosarcoma resection due to its multifunction in the future.

软骨肉瘤手术治疗后，术后组织重建可能面临严峻挑战，包括缺陷组织延迟自我修复、肿瘤复发和细菌感染。为了克服这些挑战，甲基丙烯酸酐 (MA) 改性丝胶 (SerMA) 溶液与原花青素 (PC) 负载的聚多巴胺 (PDA) 改性 ZIF-8 (PC@ZIF-8@PDA) 纳米粒子混合形成多功能 PC@ZIF- 8@PDA/SerMA 水凝胶在蓝光下曝光后。使用携带PC@ZIF-8@PDA纳米颗粒和软骨细胞的SerMA溶液打印出具有预先设计形状的水凝胶产品，表明可以通过3D打印制造具有个性化形状的PC@ZIF-8@PDA/SerMA水凝胶。光交联 PC@ZIF-8@PDA/SerMA 水凝胶能够杀死软骨肉瘤细胞和细菌，如金黄色葡萄球菌 (S. aureus)和大肠杆菌 (E. coli)，通过其光热活性与近红外辐射 (NIR) 相结合。PC@ZIF-8@PDA/SerMA 水凝胶具有抗氧化活性和良好的生物相容性，并且易于通过其荧光和光声特性进行监测。PC@ZIF-8@PDA/SerMA 水凝胶包裹相应的自体软骨细胞可有效修复兔关节软骨缺损，并通过应用该水凝胶迅速再生小鼠皮肤烧伤创面。因此，PC@ZIF-8@PDA/SerMA水凝胶具有多功能性，未来有望应用于软骨肉瘤的临床治疗和软骨肉瘤切除术后组织缺损的修复。