Aims To evaluate whether baseline vessel density (VD) parameters derived from optical coherence tomography angiography (OCT-A) is associated with the development of glaucomatous visual field (VF) defects in preperimetric glaucoma (PPG) patients. Methods One eye from each of 200 consecutive PPG patients with a normal standard automated perimetry and OCT-A at baseline was retrospectively analysed. OCT-A was used to measure the circumpapillary VD (cpVD) and the parafoveal and perifoveal VD. The retinal nerve fibre layer (RNFL) and macular ganglion cell-inner plexiform layer thicknesses were measured as reference standards. Two patient groups were stratified based on the development of repeatable glaucomatous VF loss. A Cox proportional hazards model was constructed to determine the predictive ability of OCT-A parameters for VF defects. The correlation between these baseline OCT-A parameters and the rate of global VF sensitivity loss (dB/year) was calculated using linear regression analysis. Results During a 3.1-year average follow-up period, 18 eyes (9.0%) developed glaucomatous VF defects. At baseline, the lower inferior temporal cpVD (HR (95% CI)=0.934 (0.883 to 0.988); p=0.017) and thinner inferior RNFL (HR (95% CI)=0.895 (0.839 to 0.956); p=0.001) were predictive of glaucomatous VF loss. A lower inferior temporal cpVD and thinner RNFL at baseline were associated with faster rate of global VF sensitivity loss (β=0.015; p=0.001). Conclusion In PPG eyes, a lower baseline inferior temporal cpVD is significantly associated with glaucomatous VF defect development and a faster rate of global VF loss. Data are available on reasonable request.

中文翻译：

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基线光学相干断层扫描血管造影与视野前青光眼眼青光眼视野缺损的关系

目的 评估光学相干断层扫描血管造影 (OCT-A) 得出的基线血管密度 (VD) 参数是否与视野前青光眼 (PPG) 患者青光眼视野 (VF) 缺损的发生有关。方法 对基线时标准自动视野检查和 OCT-A 正常的 200 名连续 PPG 患者每人的一只眼睛进行回顾性分析。OCT-A 用于测量视盘周围 VD (cpVD) 以及中心凹旁和中心凹周围 VD。测量视网膜神经纤维层（RNFL）和黄斑神经节细胞内丛状层厚度作为参考标准。根据可重复性青光眼室颤消失的情况对两个患者组进行分层。构建 Cox 比例风险模型以确定 OCT-A 参数对 VF 缺陷的预测能力。使用线性回归分析计算这些基线 OCT-A 参数与整体 VF 敏感性损失率（dB/年）之间的相关性。结果 在平均 3.1 年的随访期内，18 只眼睛 (9.0%) 出现青光眼性 VF 缺陷。基线时，较低的下颞 cpVD（HR（95% CI）=0.934（0.883 至 0.988）；p=0.017）和较薄的下颞 cpVD（HR（95% CI）=0.895（0.839 至 0.956）；p=0.001）是青光眼性 VF 丧失的预测。基线时较低的颞下 cpVD 和较薄的 RNFL 与整体 VF 敏感性丧失速度较快相关（β=0.015；p=0.001）。结论 在 PPG 眼中，较低的基线颞下 cpVD 与青光眼 VF 缺损的发展和整体 VF 丧失的更快速度显着相关。可根据合理要求提供数据。