Human papillomaviruses (HPVs) are extremely widespread throughout the world. There are more than 100 types of HPVs, of which at least 14 types represent high oncogenic risk viruses (World Health Organization, 2020). Numerous attempts were made to analyze various water sources in order to (i) reveal the presence of DNA of pathogenic human papillomaviruses in them and (ii) assess the potential risks of occurrence of epidemics caused by HPV. With time, the necessity to solve these important problems stimulated the formation of a new direction in the world medical and environmental investigations.

This paper contains the investigation of the presence of DNA of highly dangerous types of human papillomaviruses (HPV6, HPV11, HPV16 and HPV18) in water bodies of the Baikal natural territory, in particular in the water reservoirs in and near the villages of Listvyanka, Bolshiye Koty, Kultuk and the cities of Baikalsk and Slyudyanka. In course of our work, the conditions good for the study of the biological material obtained from water samples by the PCR technique to reveal the presence of DNA of HPV6, HPV11, HPV16 and HPV18 papillomaviruses were chosen. PCR analysis was conducted with the aid of both the already well-known universal primers GP5 + /6 + and the primers developed by our team to be applied to the conservative domains of nucleotide sequences encoding the main capsid protein L1 of human papillomaviruses HPV6, HPV11 (these types of the virus contribute to the occurrence of anogenital condylomatosis and the development of respiratory papillomatosis) and HPV16, HPV16 (these types of virus contribute to the occurrence of cervical cancer).

The analyzes conducted by our team have revealed the presence of DNA of the four types of HPVs (6, 11, 16 and 18) in the samples taken from various water sources of the Baikal natural territory.

人乳头瘤病毒 (HPV) 在世界范围内极为普遍。HPV 有 100 多种类型，其中至少有 14 种是高致癌风险病毒（世界卫生组织，2020 年）。为了 (i) 揭示其中存在致病性人乳头瘤病毒 DNA 和 (ii) 评估发生由 HPV 引起的流行病的潜在风险，人们进行了许多尝试来分析各种水源。随着时间的推移，解决这些重要问题的必要性激发了世界医学和环境研究新方向的形成。

本文包含对贝加尔湖自然领土水体中高度危险的人乳头瘤病毒（HPV6、HPV11、HPV16 和 HPV18）DNA 存在的调查，特别是在 Listvyanka、Bolshiye 村及其附近的水库中科蒂、库尔图克和贝加尔斯克市和斯柳江卡市。在我们的工作过程中，选择了有利于通过 PCR 技术研究从水样中获得的生物材料以揭示 HPV6、HPV11、HPV16 和 HPV18 乳头瘤病毒 DNA 存在的条件。借助众所周知的通用引物 GP5 + /6 + 和我们团队开发的用于编码人乳头瘤病毒 HPV6 的主要衣壳蛋白 L1 的核苷酸序列的保守结构域进行 PCR 分析，

我们团队进行的分析揭示了从贝加尔湖自然领地的各种水源采集的样本中存在四种类型的 HPV（6、11、16 和 18）的 DNA。