Engineered signaling proteins permit precise modulation of cell signaling networks and are valuable tools for basic and translational research. In this issue of Structure, Tichy and colleagues leverage high-resolution GPCR-G protein complex structures to rationally design improved light-activated chimeric GPCRs (termed OptoXRs) with increased sensitivity and tunable signaling features.

中文翻译：

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来自 G 蛋白偶联受体复合物的结构见解使改进的光激活设计受体的合理工程成为可能

工程信号蛋白允许精确调节细胞信号网络，是基础和转化研究的宝贵工具。在本期Structure中，Tichy 及其同事利用高分辨率 GPCR-G 蛋白复合物结构来合理设计改进的光激活嵌合 GPCR（称为 OptoXR），具有更高的灵敏度和可调谐的信号特征。