Purpose/Objective Research: This study examined combinations of disease outcomes (i.e., walking, cognition, and symptoms) as correlates of physical activity subgroups (insufficiently active vs. sufficiently active) in persons with multiple sclerosis (MS). RESEARCH METHOD/DESIGN This study included 213 participants who completed walking and cognitive function tests and self-report measures of symptoms and physical activity. Multivariate analysis of variance and discriminant function analysis identified combinations of MS outcomes associated with physical activity. RESULTS The sample had a mean age of 49.6 years (SD = 13.2), a 3:1 female:male ratio, and a Patient Determined Disease Steps median (interquartile range) score of 1.0 (3.0). Multivariate analysis of variance demonstrated that MS outcome clusters were significantly associated with physical activity, namely walking (i.e., Six-Minute Walk, Timed Up and Go, and MS Walking Scale), Pillai's trace V = .16, F(3, 180) = 11.43, η² = .16; cognition (i.e., Symbol Digits Modalities Test, California Verbal Learning Test-Second Edition, Brief Visuospatial Memory Test-Revised), Pillai's trace V = .04, F(3, 204) = 2.79, η² = .04; and symptoms (i.e., fatigue, anxiety, depression, and pain), Pillai's trace V = .16, F(4, 199) = 9.30, η² = .16. Discriminant function analysis indicated that a significant discriminant function of walking endurance and walking limitations, depression, fatigue, and processing speed was associated with physical activity subgroups. CONCLUSION/IMPLICATIONS The findings identified walking endurance and limitations, processing speed, depression, and fatigue as primary correlates of physical activity differences in persons with MS. These results may inform researchers and health care providers to consider these factors in behavior change interventions and clinical practices for promoting adequate physical activity levels in MS. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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多发性硬化症疾病结果与体力活动的关联：一项横断面研究。

目的/目的研究：本研究考察了多发性硬化症 (MS) 患者的疾病结果（即行走、认知和症状）组合与体力活动亚组（活动不足与充分活动）的相关性。研究方法/设计 这项研究包括 213 名参与者，他们完成了步行和认知功能测试以及症状和体力活动的自我报告测量。多变量方差分析和判别函数分析确定了与体力活动相关的 MS 结果的组合。结果 样本的平均年龄为 49.6 岁 (SD = 13.2)，女性与男性的比例为 3:1，患者确定的疾病步骤中位数（四分位距）得分为 1.0 (3.0)。多变量方差分析表明，MS 结果簇与体力活动显着相关，即步行（即六分钟步行、计时起身和 MS 步行量表）、Pillai 迹线 V = .16、F(3, 180) = 11.43，η² = .16；认知（即符号数字模态测试、加州语言学习测试第二版、简短视觉空间记忆测试修订版）、Pillai 迹 V = .04、F(3, 204) = 2.79、η² = .04；和症状（即疲劳、焦虑、抑郁和疼痛），Pillai 迹线 V = .16，F(4, 199) = 9.30，η² = .16。判别函数分析表明，步行耐力和步行限制、抑郁、疲劳和处理速度的显着判别函数与身体活动亚组相关。结论/意义 研究结果表明，步行耐力和限制、处理速度、抑郁和疲劳是多发性硬化症患者体力活动差异的主要相关因素。这些结果可能会告知研究人员和医疗保健提供者在行为改变干预措施和临床实践中考虑这些因素，以促进多发性硬化症患者充分的身体活动水平。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。