Multi-modal biomedical imaging has played an essential role in tumor diagnosis. However, constructing a multi-modal imaging contrast agent with high affinity to a tumor is challenging. Herein, we studied the design and application of a PET/MRI dual-modal imaging agent based on superparamagnetic iron oxide nanoparticles (SPION). α_vβ₃-targeting RGD peptide and ⁶⁴Cu were conjugated onto SPION. Small animal PET and MR imaging in glioblastoma tumor-bearing mice revealed that this dual-modal imaging contrast agent could potentially be utilized for PET/MRI dual-modal imaging for the tumor diagnosis.

中文翻译：

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一种新型潜在αvβ3靶向PET/MRI双模显像剂的制备和体内成像

多模态生物医学成像在肿瘤诊断中发挥了重要作用。然而，构建对肿瘤具有高亲和力的多模式成像造影剂具有挑战性。在此，我们研究了基于超顺磁性氧化铁纳米粒子（SPION）的 PET/MRI 双模态显像剂的设计和应用。将α _v β ₃靶向 RGD 肽和⁶⁴ Cu 缀合到 SPION 上。胶质母细胞瘤荷瘤小鼠的小动物 PET 和 MR 成像显示，这种双模成像造影剂有可能用于 PET/MRI 双模成像以进行肿瘤诊断。