Direct Construction of Julolidines via Reductive Annulation of Quinolines and Conjugated Enones by a MOF-Derived Hierarchically Porous Iridium Catalyst,ACS Catalysis

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Direct Construction of Julolidines via Reductive Annulation of Quinolines and Conjugated Enones by a MOF-Derived Hierarchically Porous Iridium Catalyst
ACS Catalysis ( IF 11.3 ) Pub Date : 2022-08-05 , DOI: 10.1021/acscatal.2c02573
Huanhuan Jia ₁ , Rong Xie ₁ , Guangpeng Lu ₁ , Huanfeng Jiang ₁ , Min Zhang ₁

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Here, we describe the development of a MOF-derived hierarchically porous ZrO₂-supported iridium catalyst (Ir-N@HP-_mesoZrO₂), featuring sufficient accessible catalytic sites even with ultralow iridium loading. Such a catalyst was successfully applied to selective and direct construction of julolidines via catalytic reductive annulation of readily available quinolines and conjugated enones, proceeding with good substrate and functional group compatibility, reusable catalyst, high step and atom efficiency, and easy applicability for the fabrication of functional molecules. The present work opens a door to further develop useful transformations by merging hydrogen transfer-mediated substrate activation with in situ incorporation of a coupling sequence under heterogeneous reductive catalysis.

中文翻译：

MOF 衍生的分层多孔铱催化剂通过喹啉和共轭烯酮的还原环化直接构建 Julolidines

在这里，我们描述了 MOF 衍生的分层多孔 ZrO ₂负载的铱催化剂（Ir-N@HP- _meso ZrO ₂)，即使在铱负载量超低的情况下，也具有足够的可及催化位点。该催化剂成功地应用于通过催化还原环化容易获得的喹啉和共轭烯酮选择性和直接构建julolins，具有良好的底物和官能团相容性，可重复使用的催化剂，高步骤和原子效率，易于制备功能分子。目前的工作通过在非均相还原催化下将氢转移介导的底物活化与原位结合的偶联序列相结合，为进一步开发有用的转化打开了大门。

更新日期：2022-08-05

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