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Depletion of ARGs in antibiotic-resistance Klebsiella, Pseudomonas and Staphylococcus in hospital urines by electro and photo-electro disinfection
Journal of Water Process Engineering ( IF 6.3 ) Pub Date : 2022-08-05 , DOI: 10.1016/j.jwpe.2022.103035
Miguel Herraiz-Carboné , Salvador Cotillas , Engracia Lacasa , Pablo Cañizares , Manuel A. Rodrigo , Cristina Sáez

The depletion of blaKPC (K. pneumoniae), blaOXA-50 (P. aeruginosa) and mecA (S. aureus) genes from hospital urines is evaluated to contribute to solve the silent pandemic of antibiotic-resistance bacteria. A microfluidic flow-through reactor with MMO anode and CB/PTFE cathode working at 50 A m−2 is employed during electrodisinfection and photo-electrodisinfection processes. The electrodisinfection process only achieves an almost negligible removal of DNA and slightly log ARG increments of 0.18, 0.19 and 0.71 for blaOXA-50, mecA and blaKPC genes, respectively. Conversely, the photo-electrodisinfection process attains the complete disinfection for all ARB tested and logarithmic removals of 3.70, 2.25 and 0.82 for blaOXA-50, mecA and blaKPC genes, respectively. These outcomes emphasize the potential of the UV light coupled to the electrodisinfection process to promote the formation of not only hypochlorite but also chlorine and even nitrogen radicals, which contribute to enhance the disinfection efficiency of the target ARB and their ARGs.



中文翻译:

通过电和光电消毒去除医院尿液中耐药克雷伯菌、假单胞菌和葡萄球菌中的 ARGs

评估医院尿液中bla KPC肺炎克雷伯菌)、bla OXA-50铜绿假单胞菌)和mec A(金黄色葡萄球菌)基因的消耗有助于解决抗生素耐药性细菌的无声大流行。在电消毒和光电消毒过程中使用了具有 MMO 阳极和 CB/PTFE 阴极的微流体流通式反应器,工作电流为 50 A m -2 。对于bla OXA-50mec A 和bla KPC ,电消毒过程仅实现了几乎可以忽略不计的 DNA 去除和 0.18、0.19 和 0.71 的轻微对数 ARG 增量基因,分别。相反,光电消毒过程实现了对所有 ARB 测试的完全消毒,对bla OXA-50mec A 和bla KPC基因的对数去除率分别为 3.70、2.25 和 0.82。这些结果强调了紫外线与电消毒过程相结合的潜力,不仅可以促进次氯酸盐的形成,还可以促进氯甚至氮自由基的形成,这有助于提高目标 ARB 及其 ARG 的消毒效率。

更新日期:2022-08-05
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