A Rapid and High-Throughput Assay for Light Scattering of SARS-CoV-2 Virion-Sized Particulates via Microfluidic Spray Device Reveals the Protection Performance of Face Masks against Virus Infection,Nano Letters

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A Rapid and High-Throughput Assay for Light Scattering of SARS-CoV-2 Virion-Sized Particulates via Microfluidic Spray Device Reveals the Protection Performance of Face Masks against Virus Infection
Nano Letters ( IF 9.6 ) Pub Date : 2022-08-05 , DOI: 10.1021/acs.nanolett.2c02278
Young Joon Sung ₁ , Sojin Song ₁ , Sang Jun Sim ₁

Affiliation

To prevent interhuman transmission of viruses, new mask types─claiming improved filtration─require careful performance characterization. Here, a microfluidic spray device that can effectively simulate droplets emitted during coughing or sneezing was developed to spray droplets containing gold nanoparticles (AuNPs) that mimic SARS-CoV-2 to overcome the shortcomings associated with using biosamples. The light scattered by the AuNPs passing through the mask is successfully analyzed by using an automated scattering light mapping system within a duration of 2 min, thereby enabling high-throughput analysis of the filtering efficiency of various types of commercial masks. The differences in efficiency in terms of same mask type from different manufacturers, double masking, and prolonged usage, which are challenging to analyze with conventional testing systems, can also be assessed. AuNP-mediated mask performance evaluation enables the rapid determination of mask efficiency according to particle size and can contribute to the rapid response to counter new emerging infectious biohazards.

中文翻译：

通过微流体喷雾装置对 SARS-CoV-2 病毒粒子大小的颗粒进行光散射的快速高通量测定揭示了口罩对病毒感染的保护性能

为了防止病毒在人与人之间传播，新的口罩类型——声称改进了过滤——需要仔细的性能表征。在这里，开发了一种可以有效模拟咳嗽或打喷嚏时发出的液滴的微流控喷雾装置，用于喷射含有模拟 SARS-CoV-2 的金纳米粒子 (AuNP) 的液滴，以克服与使用生物样本相关的缺点。通过使用自动散射光映射系统在 2 分钟的时间内成功地分析了 AuNPs 穿过掩模的散射光，从而能够对各种类型的商业掩模的过滤效率进行高通量分析。不同厂家的同种口罩、双重口罩、长时间使用等在效率上的差异，使用传统测试系统难以分析的问题也可以进行评估。AuNP 介导的面罩性能评估能够根据颗粒大小快速确定面罩效率，并有助于快速应对新出现的传染性生物危害。

更新日期：2022-08-05

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