Background

Dermatitis localized to hands (HD), feet (FD), or both hands and feet (HFD) has multiple etiologies, including atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis. Unfortunately, little is known about clinical differences between patients with HD, FD, and HFD.

Objective

To characterize differences in demographics, etiology, and patch testing results among patients presenting with HD, FD, or HFD referred for patch testing.

Methods

A retrospective analysis of patients patch tested by the North American Contact Dermatitis Group between 2001 and 2018.

Results

Of 43,677 patients who were patch tested, 22.8% had HD, 2.9% had FD, and 3.7% had HFD. Allergic and currently relevant patch test reactions to ≥1 North American Contact Dermatitis Group screening allergen occurred in similar proportions in all 3 study groups. However, HD (18.0%) had higher proportions of occupationally relevant reactions than HFD (8.9%) or FD (4.0%). Nickel and fragrance mix I were in the top 5 currently relevant allergens for HD, FD, and HFD. Other top allergens, as well as allergen sources, differed between HD, FD, and HFD.

Limitations

No data on HD or FD morphology or distribution.

Conclusion

HD, FD, and HFD have several differences with respect to patient characteristics, etiologies, and clinically relevant allergens.

中文翻译：

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2001-2018 年北美接触性皮炎组数据分析转诊进行斑贴测试的患者的手足皮炎

背景

局限于手 (HD)、足部 (FD) 或手和足部 (HFD) 的皮炎有多种病因，包括特应性皮炎、刺激性接触性皮炎和过敏性接触性皮炎。不幸的是，对于 HD、FD 和 HFD 患者之间的临床差异知之甚少。

客观的

描述因 HD、FD 或 HFD 转诊进行斑贴测试的患者在人口统计学、病因学和斑贴测试结果方面的差异。

方法

北美接触性皮炎小组在 2001 年至 2018 年间测试的患者贴片的回顾性分析。

结果

在接受斑贴测试的 43,677 名患者中，22.8% 患有 HD，2.9% 患有 FD，3.7% 患有 HFD。在所有 3 个研究组中，对≥1 种北美接触性皮炎组筛查过敏原的过敏和目前相关的斑贴试验反应发生的比例相似。然而，HD (18.0%) 的职业相关反应比例高于 HFD (8.9%) 或 FD (4.0%)。镍和香料混合物 我是目前与 HD、FD 和 HFD 相关的前 5 种过敏原。HD、FD 和 HFD 之间的其他主要过敏原以及过敏原来源不同。

限制

没有关于 HD 或 FD 形态或分布的数据。

结论

HD、FD 和 HFD 在患者特征、病因和临床相关过敏原方面存在一些差异。