In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes the notion that the cumulative inflammatory events over the course of an organism’s lifespan may irreversibly damage LT-HSCs.

中文翻译：

---

时钟拨快：炎症加速造血干细胞衰老

在最新一期的细胞干细胞中，Bogeska 等人。证明反复暴露于炎症会导致不可磨灭的特定功能损害并加速长期造血干细胞 (LT-HSC) 的老化。这项研究提出了这样一种观点，即生物体生命周期中累积的炎症事件可能不可逆转地损害 LT-HSC。