Herein, a highly efficient electro-peroxone (E-peroxone) process with graphite felt as ozone diffusion electrode (ODE) was developed for the synchronous removal of pharmaceutical contaminants and inactivation of pathogenic microorganisms in real hospital wastewater. Under optimal conditions, the total organic carbon (TOC) removal rate of real hospital wastewater could reach 93.9%. Importantly, 126 pharmaceutical compounds (antibiotics, antivirals, analgesics, antiepileptics, hormones, and others) were determined in hospital wastewater by using ultra performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS). 110 pharmaceutical compounds could be efficiently degraded in E-peroxone system. Concurrently, the microbial community analysis through high-throughput sequencing showed that E-peroxone process exhibited an excellent disinfection effect in real hospital wastewater. Escherichia coli as a bacterial indicator could be completely inactivated in E-peroxone process·H₂O₂ and hydroxyl radical (OH) were found in E-peroxone system based on the results of chemical probe experiments and electron paramagnetic resonance (EPR) analysis. The in-situ generation of H₂O₂ from cathodic oxygen reduction in ODE can react with ozone to produce OH, and realize high efficiencies for the elimination of pharmaceutical and sterilization. This work established a green and effective way without extra addition of chemical reagents for high-efficiency treatment of real hospital wastewater.

本文开发了一种以石墨毡作为臭氧扩散电极（ODE）的高效电过氧酮（E-peroxone）工艺，用于同步去除真实医院废水中的药物污染物和灭活病原微生物。在最佳条件下，真实医院废水的总有机碳（TOC）去除率可达93.9%。重要的是，使用超高效液相色谱结合四极杆飞行时间质谱 (UPLC-Q-TOF-MS/MS) 测定了医院废水中的 126 种药物化合物（抗生素、抗病毒药、镇痛药、抗癫痫药、激素等） ）。E-peroxone 体系可有效降解 110 种药物化合物。同时，通过高通量测序进行的微生物群落分析表明，E-peroxone工艺在真实医院废水中表现出优异的消毒效果。E -peroxone过程中作为细菌指示剂的大肠杆菌可以被完全灭活·根据化学探针实验和电子顺磁共振(EPR)分析结果，在E-peroxone体系中发现了H ₂ O ₂和羟基自由基( OH)。ODE中阴极氧还原原位生成H ₂ O ₂，​​可与臭氧反应生成OH，实现高效的药剂消除和灭菌。该工作为真实医院废水的高效处理建立了一种无需额外添加化学试剂的绿色有效的方法。