Background

The clinical importance of morningness-eveningness, especially in mood disorders, is prevailing. The differential relation of chronotype with diagnoses of early-onset mood disorders, mood symptoms, anxiety, and quality of life was evaluated.

Methods

Early-onset mood disorder patients [n = 419; 146 major depressive disorder (MDD); 123 bipolar I disorder (BDI); 150 bipolar II disorder (BDII)] from the Mood Disorder Cohort Research Consortium were assessed for chronotype using the composite scale for morningness (CSM) and its association with clinical variables obtained during the clinician-verified euthymic state.

Results

The mean total CSM of BDI was significantly higher than MDD and BDII (p < 0.001). In all types of mood disorders, higher total CSM was associated with lower Quick inventory of depressive symptomatology (p < 0.005) and higher WHO quality of life (p < 0.005). Such negative correlations between the total CSM and Montgomery-Asberg depression rating were significant in MDD and BDI (p < 0.05) and marginally significant in BDII (p = 0.077). CSM was a significant contributor to quality of life in BDI (p < 0.001) and BDII (p = 0.011), but it was not for MDD.

Limitations

The defined ‘euthymic state’ that may not fully reflect the remission of episode; limited generalizability due to clinical characteristic of early-onset mood disorder; the disparity between diurnal preference measured by the CSM and chronotype; possible effects of the last mood episode polarity and medication; and, lack of control group.

Conclusion

Less eveningness was associated with less severe depressive symptoms and better quality of life. This suggests that morningness may reduce residual depressive symptoms and recover function of patients.

中文翻译：

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情绪障碍正常状态下早晚与情绪症状和生活质量之间的关系：一项前瞻性观察队列研究的结果

背景

早晚的临床重要性，特别是在情绪障碍中，是普遍的。评估了表型与早发性情绪障碍、情绪症状、焦虑和生活质量诊断的差异关系。

方法

早发性情绪障碍患者 [ n  = 419；146 种重度抑郁症（MDD）；123 双相 I 型障碍 (BDI)；来自情绪障碍队列研究联盟的 150 例双相 II 型障碍 (BDII)] 使用早晨的复合量表 (CSM) 评估了时间型，及其与在临床医生验证的正常状态期间获得的临床变量的关联。

结果

BDI 的平均总 CSM 显着高于 MDD 和 BDII ( p  < 0.001)。在所有类型的情绪障碍中，较高的总 CSM 与较低的抑郁症状快速清单 ( p  < 0.005) 和较高的 WHO 生活质量 (p < 0.005) 相关。总 CSM 和 Montgomery-Asberg 抑郁评分之间的这种负相关在 MDD 和 BDI 中显着（p  < 0.05），在 BDII 中显着（p  = 0.077）。CSM 对 BDI ( p  < 0.001) 和 BDII ( p = 0.011)的生活质量有显着贡献 ，但对 MDD 没有影响。

限制

定义的“正常状态”可能无法完全反映发作的缓解；由于早发性情绪障碍的临床特征，可推广性有限；由 CSM 测量的昼夜偏好与表型之间的差异；最后一次情绪发作极性和药物的可能影响；并且，缺乏对照组。

结论

较少的晚上与较轻的抑郁症状和更好的生活质量有关。这表明早晨可以减少残留的抑郁症状并恢复患者的功能。