Immediate, Remote Smoking Cessation Intervention in Participants Undergoing a Targeted Lung Health Check: Quit Smoking Lung Health Intervention Trial, a Randomized Controlled Trial,Chest

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Immediate, Remote Smoking Cessation Intervention in Participants Undergoing a Targeted Lung Health Check: Quit Smoking Lung Health Intervention Trial, a Randomized Controlled Trial
Chest ( IF 9.5 ) Pub Date : 2022-08-04 , DOI: 10.1016/j.chest.2022.06.048
Parris J Williams ₁ , Keir E J Philip ₂ , Navjot Kaur Gill ₃ , Deirdre Flannery ₃ , Sara Buttery ₂ , Emily C Bartlett ₃ , Anand Devaraj ₄ , Samuel V Kemp ₃ , Jamie Addis ₃ , Jane Derbyshire ₅ , Michelle Chen ₅ , Katie Morris ₅ , Anthony A Laverty ₆ , Nicholas S Hopkinson ₂

Affiliation

Lung cancer screening programs provide an opportunity to support people who smoke to quit, but the most appropriate model for delivery remains to be determined. Immediate face-to-face smoking cessation support for people undergoing screening can increase quit rates, but it is not known whether remote delivery of immediate smoking cessation counselling and pharmacotherapy in this context also is effective. Does an immediate telephone smoking cessation intervention increase quit rates compared with usual care among a population enrolled in a targeted lung health check (TLHC)? In a single-masked randomized controlled trial, people 55 to 75 years of age who smoke and attended a TLHC were allocated by day of attendance to receive either immediate telephone smoking cessation intervention (TSI) support (starting immediately and lasting for 6 weeks) with appropriate pharmacotherapy or usual care (UC; very brief advice to quit and signposting to smoking cessation services). The primary outcome was self-reported 7-day point prevalence smoking abstinence at 3 months. Differences between groups were assessed using logistic regression. Three hundred fifteen people taking part in the screening program who reported current smoking with a mean ± SD age of 63 ± 5.4 years, 48% of whom were women, were randomized to TSI (n = 152) or UC (n = 163). The two groups were well matched at baseline. Self-reported quit rates were higher in the intervention arm, 21.1% vs 8.9% (OR, 2.83; 95% CI, 1.44-5.61; = .002). Controlling for participant demographics, neither baseline smoking characteristics nor the discovery of abnormalities on low-dose CT imaging modified the effect of the intervention. Immediate provision of an intensive telephone-based smoking cessation intervention including pharmacotherapy, delivered within a targeted lung screening context, is associated with increased smoking abstinence at 3 months. ISRCTN registry; No.: ISRCTN12455871; URL:

中文翻译：

对接受有针对性的肺部健康检查的参与者进行立即、远程戒烟干预：戒烟肺部健康干预试验，一项随机对照试验

肺癌筛查项目为支持吸烟者戒烟提供了机会，但最合适的实施模式仍有待确定。为接受筛查的人提供立即面对面的戒烟支持可以提高戒烟率，但尚不清楚在这种情况下远程提供立即戒烟咨询和药物治疗是否也有效。在参加有针对性的肺部健康检查（TLHC）的人群中，与常规护理相比，立即电话戒烟干预是否会提高戒烟率？在一项单盲随机对照试验中，参加 TLHC 的 55 至 75 岁吸烟者按参加日分配接受立即电话戒烟干预 (TSI) 支持（立即开始并持续 6 周）和适当的药物治疗或常规护理（UC；非常简短的戒烟建议和戒烟服务路标）。主要结局是自我报告的 3 个月时戒烟 7 天点患病率。使用逻辑回归评估组之间的差异。参加筛查计划的 315 名平均±标准差年龄为 63±5.4 岁的吸烟者（其中 48% 是女性）被随机分配至 TSI（n = 152）或 UC（n = 163）。两组在基线时匹配良好。干预组的自我报告戒烟率较高，分别为 21.1% 和 8.9%（OR，2.83；95% CI，1.44-5.61；= .002）。控制参与者的人口统计数据后，基线吸烟特征和低剂量 CT 成像异常的发现都不会改变干预的效果。立即提供基于电话的强化戒烟干预措施，包括在有针对性的肺部筛查背景下进行的药物治疗，与 3 个月时戒烟率的提高有关。 ISRCTN 注册表；编号：ISRCTN12455871；网址：

更新日期：2022-08-04

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