Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications,Journal of the American Chemical Society

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Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2022-08-04 , DOI: 10.1021/jacs.2c03437
Lawrence Cho-Cheung Lee _{1,

2} , Kenneth Kam-Wing Lo _{1,

3}

Affiliation

There has been emerging interest in the exploitation of the photophysical and photochemical properties of transition metal complexes for diagnostic and therapeutic applications. In this Perspective, we highlight the major recent advances in the development of luminescent and photofunctional transition metal complexes, in particular, those of rhenium(I), ruthenium(II), osmium(II), iridium(III), and platinum(II), as bioimaging reagents and phototherapeutic agents, with a focus on the molecular design strategies that harness and modulate the interesting photophysical and photochemical behavior of the complexes. We also discuss the current challenges and future outlook of transition metal complexes for both fundamental research and clinical applications.

中文翻译：

发光和光功能过渡金属配合物：从分子设计到诊断和治疗应用

人们对利用过渡金属配合物的光物理和光化学性质进行诊断和治疗应用的兴趣日益浓厚。在本期展望中，我们重点介绍了发光和光功能过渡金属配合物的最新进展，特别是铼（I）、钌（II）、锇（II）、铱（III）和铂（II） )，作为生物成像试剂和光治疗剂，重点关注利用和调节复合物有趣的光物理和光化学行为的分子设计策略。我们还讨论了过渡金属配合物在基础研究和临床应用方面的当前挑战和未来前景。

更新日期：2022-08-04

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