Visible Light Photoredox-Catalyzed Direct C–H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts,The Journal of Organic Chemistry

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Visible Light Photoredox-Catalyzed Direct C–H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-08-04 , DOI: 10.1021/acs.joc.2c01234
Raj K Samanta ₁ , Prahallad Meher ₁ , Sandip Murarka ₁

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A photoredox-catalyzed direct arylation of quinoxalin-2-(1H)-ones using diaryliodonium triflates as the convenient, stable, and cheap aryl source is described. A broad variety of quinoxalin-2-(1H)-ones are shown to react with structurally and electronically diverse diaryliodonium triflates, allowing efficient access to a wide variety of pharmaceutically important 3-arylquinoxalin-2-(1H)-ones. The presented method is attractive with regard to operational simplicity, mild conditions, broad scope, scalability, and high functional group tolerance.

中文翻译：

可见光光氧化还原催化 Quinoxalin-2(1H)-one 与二芳基碘鎓盐的直接 C-H 芳基化

描述了使用二芳基碘鎓三氟甲磺酸盐作为方便、稳定和廉价的芳基来源的 quinoxalin-2-(1 H )-ones 的光氧化还原催化直接芳基化。多种 quinoxalin-2-(1 H )-ones 可与结构和电子不同的二芳基碘鎓三氟甲磺酸盐反应，从而可以有效地获得多种药学上重要的 3-arylquinoxalin-2-(1 H )-ones。所提出的方法在操作简单、条件温和、范围广、可扩展性和高官能团耐受性方面具有吸引力。

更新日期：2022-08-04

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