Hypersampones A–C, Three Nor-Polycyclic Polyprenylated Acylphloroglucinols with Lipid-Lowering Activity from Hypericum sampsonii,Organic Letters

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Hypersampones A–C, Three Nor-Polycyclic Polyprenylated Acylphloroglucinols with Lipid-Lowering Activity from Hypericum sampsonii
Organic Letters ( IF 4.9 ) Pub Date : 2022-08-04 , DOI: 10.1021/acs.orglett.2c02240
Lei Huang _{1,

2} , Zi-Zhen Zhang _{1,

2} , Ya-Nan Li _{1,

2} , Ping Yi _{1,

2} , Wei Gu _{1,

2} , Jue Yang _{1,

2} , Yan-Mei Li _{1,

2} , Xiao-Jiang Hao _{1,

2,

3} , Chun-Mao Yuan _{1,

2}

Affiliation

Hypersampones A–C (1–3), three unprecedented nor-polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum sampsonii. These compounds represent the first nor-PPAPs with an unexpected tetracyclic 6/5/5/6 ring system. Their structures were assigned through the analysis of detailed spectroscopic data, X-ray crystallography, and electronic circular dichroism calculations. Compound 1 significantly inhibited the accumulation of lipid in an oleic acid-treated HepG2 cell model by suppressing the protein expression of FAS and ACACA at 5 μM.

中文翻译：

Hypersampones A–C, 来自金丝桃属植物的三种具有降脂活性的去甲多环聚异戊二烯酰间苯三酚

Hypersampones A-C ( 1-3 )，三种前所未有的去甲多环聚异戊二烯酰间苯三酚 (PPAPs)，从金丝桃中分离得到。这些化合物代表了第一个具有意想不到的四环 6/5/5/6 环系统的 nor-PPAP。它们的结构是通过分析详细的光谱数据、X 射线晶体学和电子圆二色性计算来确定的。化合物1通过在 5 μM 时抑制 FAS 和 ACACA 的蛋白质表达，显着抑制油酸处理的 HepG2 细胞模型中脂质的积累。

更新日期：2022-08-04

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