A nickel-catalyzed intramolecular conjunctive cross-electrophile coupling reaction has been established. This method enables the synthesis of 3,5-vicinal carbocyclic rings found in numerous biologically active compounds and natural products. We provide mechanistic experiments that indicate this reaction proceeds through alkyl iodides formed in situ, initiates at the secondary electrophilic center, and proceeds through radical intermediates.

中文翻译：

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分子内镍催化的连接交叉电偶联反应合成邻位碳环

已经建立了镍催化的分子内连接交叉亲电偶联反应。该方法能够合成在许多生物活性化合物和天然产物中发现的 3,5-邻位碳环。我们提供的机械实验表明该反应通过原位形成的烷基碘进行，在次级亲电中心引发，并通过自由基中间体进行。