We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

中文翻译：

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慢性感染免疫功能低下者中高度分化的 SARS-CoV-2 Alpha 变体

在荷兰最新检测到 Alpha 变体几个月后，我们在一名免疫功能低下的人身上检测到了高度不同的 SARS-CoV-2 Alpha 变体。尽管接受了多种治疗方案并且大多数临床症状消失，患者仍被感染了 42 周。我们在刺突蛋白中发现了几种潜在的免疫逃逸突变。