Metal-free synthesis of 3,3′-bisindolylmethanes in water using Ph3C+[B(C6F5)4]− as the pre-catalyst,Organic Chemistry Frontiers

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Metal-free synthesis of 3,3′-bisindolylmethanes in water using Ph3C+[B(C6F5)4]− as the pre-catalyst
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2022-08-04 , DOI: 10.1039/d2qo01081j
Zhenguo Zhang ₁ , Liang Ji ₁ , Xiaoxiao Liu ₁ , Zhihong Li ₂ , Yongheng Lv ₁ , Zhenhua Jia ₁ , Teck-Peng Loh _{3,

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Affiliation

Here, we report a highly efficient catalytic species generated from Ph₃C⁺[B(C₆F₅)₄]⁻ by the water mediated Friedel–Crafts type reaction of indoles with carbonyl compounds to afford 3,3′-bisindolylmethanes (BIMs). This scalable method is applicable to a wide variety of carbonyl compounds, including unprotected sugar molecules and carbonyl compounds derived from drugs and natural products.

中文翻译：

使用 Ph3C+[B(C6F5)4]- 作为预催化剂在水中无金属合成 3,3'-二吲哚基甲烷

在这里，我们报道了一种高效的催化物质，由 Ph ₃ C ⁺ [B(C ₆ F ₅ ) ₄ ] ^-通过水介导的吲哚与羰基化合物的 Friedel-Crafts 型反应生成 3,3'-二吲哚基甲烷 (BIMs ）。这种可扩展的方法适用于多种羰基化合物，包括未受保护的糖分子和源自药物和天然产物的羰基化合物。

更新日期：2022-08-04

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