A direct, catalytic, and complementary method to obtain 2-substituted homoallyl sulfonyl amides is described, starting from sulfonyl amides, aldehydes, and allyltrimethylsilane using iron(III) chloride as a sustainable catalyst. The scope of the process and the reactivity in aza-Prins cyclization is evaluated and supported by density functional theory (DFT) studies. Finally, an evaluation of the antiproliferative activity for this family of sulfonyl amides is also included.

中文翻译：

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铁(III)-催化合成2-烷基高烯丙基磺酰胺：氮杂-普林斯环化的抗增殖研究和反应范围

描述了一种直接、催化和互补的方法来获得 2-取代的高烯丙基磺酰胺，从磺酰胺、醛和烯丙基三甲基硅烷开始，使用氯化铁 (III) 作为可持续催化剂。密度泛函理论 (DFT) 研究评估和支持了氮杂-普林斯环化过程的范围和反应性。最后，还包括对该磺酰酰胺家族的抗增殖活性的评估。