The development of a safe and effective active pharmaceutical ingredient (API) to be used for addressing a disease is of the utmost importance in the pharmaceutical industry. Oftentimes, the synthetic pathway required for API development involves the genesis of a chiral compound. Asymmetric syntheses are popular routes for generating these kinds of compounds; these reaction routes require a high level of attention for efficient and successful syntheses. Process analytical technology (PAT) provides significant advantages for monitoring, controlling, and assessing synthetic processes directly and in real time. In this review, PAT applications for investigating and improving asymmetric synthetic reactions are discussed. The totality of this effort provides a comprehensive and thorough repository of recent work which has advanced the pharmaceutical field for generating chiral compounds for industrial applications.

开发用于治疗疾病的安全有效的活性药物成分 (API) 在制药行业中至关重要。通常，API 开发所需的合成途径涉及手性化合物的产生。不对称合成是生成此类化合物的常用途径；这些反应路线需要高度关注才能有效且成功地合成。过程分析技术 (PAT) 为直接和实时地监测、控制和评估合成过程提供了显着优势。在这篇综述中，讨论了 PAT 在研究和改进不对称合成反应中的应用。