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T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?
Cell Metabolism ( IF 29.0 ) Pub Date : 2022-08-02 , DOI: 10.1016/j.cmet.2022.07.008 Michael P Cancro 1
中文翻译:
T-bet B 还是不 T-bet B,这是肥胖相关代谢疾病的问题吗?
更新日期:2022-08-03
Cell Metabolism ( IF 29.0 ) Pub Date : 2022-08-02 , DOI: 10.1016/j.cmet.2022.07.008 Michael P Cancro 1
Affiliation
Obesity is linked to inflammation and downstream metabolic dysregulation. In this issue of Cell Metabolism, Hägglöf et al. show that iNKT cells enable the accumulation of T-bet+ B cells in white adipose tissue, which in turn produce chemokine and antibody mediators that exacerbate the onset and severity of metabolic disease.
中文翻译:
T-bet B 还是不 T-bet B,这是肥胖相关代谢疾病的问题吗?
肥胖与炎症和下游代谢失调有关。在本期细胞代谢中,Hägglöf 等人。表明 iNKT 细胞能够使 T-bet + B 细胞在白色脂肪组织中积累,进而产生趋化因子和抗体介质,加剧代谢疾病的发作和严重程度。