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Outrunning obesity with Lac-Phe?
Cell Metabolism ( IF 27.7 ) Pub Date : 2022-08-02 , DOI: 10.1016/j.cmet.2022.07.007
Jens Lund 1 , Christoffer Clemmensen 1 , Thue W Schwartz 1
Affiliation  

Lactate released from skeletal muscle during high-intensity exercise gives rise to a surge in circulating lactate-derived pseudo-dipeptide metabolites including N-lactoyl-phenylalanine (Lac-Phe). In a recent Nature paper, Li et al. use genetic and pharmacological evidence to now propose Lac-Phe to be an “exercise hormone” that suppresses appetite and obesity.



中文翻译:

用 Lac-Phe 战胜肥胖?

高强度运动期间骨骼肌释放的乳酸会导致循环乳酸衍生的假二肽代谢物(包括 N-乳酰苯丙氨酸 (Lac-Phe))激增。在最近的一篇自然论文中,李等人。现在使用遗传和药理学证据提出 Lac-Phe 是一种抑制食欲和肥胖的“运动激素”。

更新日期:2022-08-03
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