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Fast and Selective Detection of Trace Chemical Warfare Agents Enabled by an ESIPT-Based Fluorescent Film Sensor
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-08-03 , DOI: 10.1021/acs.analchem.2c00862 Ke Liu 1 , Molin Qin 2 , Qiyuan Shi 1 , Gang Wang 1 , Jing Zhang 1 , Nannan Ding 1 , Hailing Xi 2 , Taihong Liu 1 , Jinglin Kong 2 , Yu Fang 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2022-08-03 , DOI: 10.1021/acs.analchem.2c00862 Ke Liu 1 , Molin Qin 2 , Qiyuan Shi 1 , Gang Wang 1 , Jing Zhang 1 , Nannan Ding 1 , Hailing Xi 2 , Taihong Liu 1 , Jinglin Kong 2 , Yu Fang 1
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Reliable detection of airborne chemical warfare agents (CWAs) at the site and in real-time remains a challenge due to the rarity of miniaturized analytical tools. Herein, an o-carborane-functionalized benzothiazole derivative (PCBO) with excited-state intramolecular proton transfer (ESIPT) and AIE characteristics was synthesized. The PCBO-based film sensor showed a highly sensitive response to representative simulants of CWAs, and detection limits were found to be 1.0 mg·m–3 for triphosgene, 6.0 mg·m–3 for chloroethyl ethyl sulfide, and 0.2 mg·m–3 for diethyl chlorophosphite. Moreover, the sensor showed great reusability (>100 cycles) and unprecedented response speed (<0.5 s). The excellent sensing performance was ascribed to the microenvironmental sensitivity of the sensing fluorophore, the porous adlayer structure of the film, and the specific binding of the fluorophore to the analytes. Furthermore, discrimination and identification of the examined CWA simulants were realized via the introduction of another fluorophore (HCBO)-based film. Importantly, a portable fluorescent CWA detector was built with the sensor as the key component, and its applicability was demonstrated by the successful detection of a typical CWA sample (Sarin). The present study indicates that fluorescent film sensors could satisfy reliable onsite and real-time detection of harmful chemicals.
中文翻译：
基于 ESIPT 的荧光膜传感器实现对痕量化学战剂的快速选择性检测
由于小型化分析工具的稀有性，在现场和实时可靠地检测空气中的化学战剂 (CWA) 仍然是一个挑战。在此，合成了具有激发态分子内质子转移 (ESIPT) 和 AIE 特性的邻碳硼烷官能化苯并噻唑衍生物 (PCBO)。基于 PCBO 的薄膜传感器对 CWA 的代表性模拟物表现出高度灵敏的响应，检测限为三光气 1.0 mg·m –3、氯乙基硫醚6.0 mg·m –3和 0.2 mg·m – 3用于氯亚磷酸二乙酯。此外，该传感器显示出出色的可重复使用性（>100 次循环）和前所未有的响应速度（<0.5 秒）。优异的传感性能归因于传感荧光团的微环境敏感性、薄膜的多孔层结构以及荧光团与分析物的特异性结合。此外，通过引入另一种基于荧光团 (HCBO) 的薄膜，实现了对所检查的 CWA 模拟物的区分和识别。重要的是，以传感器为关键部件构建了便携式荧光CWA检测器，并通过成功检测典型CWA样品（沙林）证明了其适用性。目前的研究表明，荧光膜传感器可以满足对有害化学物质的可靠现场和实时检测。
更新日期：2022-08-03
中文翻译：
基于 ESIPT 的荧光膜传感器实现对痕量化学战剂的快速选择性检测
由于小型化分析工具的稀有性，在现场和实时可靠地检测空气中的化学战剂 (CWA) 仍然是一个挑战。在此，合成了具有激发态分子内质子转移 (ESIPT) 和 AIE 特性的邻碳硼烷官能化苯并噻唑衍生物 (PCBO)。基于 PCBO 的薄膜传感器对 CWA 的代表性模拟物表现出高度灵敏的响应，检测限为三光气 1.0 mg·m –3、氯乙基硫醚6.0 mg·m –3和 0.2 mg·m – 3用于氯亚磷酸二乙酯。此外，该传感器显示出出色的可重复使用性（>100 次循环）和前所未有的响应速度（<0.5 秒）。优异的传感性能归因于传感荧光团的微环境敏感性、薄膜的多孔层结构以及荧光团与分析物的特异性结合。此外，通过引入另一种基于荧光团 (HCBO) 的薄膜，实现了对所检查的 CWA 模拟物的区分和识别。重要的是，以传感器为关键部件构建了便携式荧光CWA检测器，并通过成功检测典型CWA样品（沙林）证明了其适用性。目前的研究表明，荧光膜传感器可以满足对有害化学物质的可靠现场和实时检测。
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