MgI2-Catalyzed Nucleophilic Ring-Opening Reactions of Donor–Acceptor Cyclopropanes with Indoline-2-thiones,The Journal of Organic Chemistry

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MgI2-Catalyzed Nucleophilic Ring-Opening Reactions of Donor–Acceptor Cyclopropanes with Indoline-2-thiones
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-08-02 , DOI: 10.1021/acs.joc.2c01179
Pan Tang ₁ , You-Yuan Wei ₁ , Long Wen ₁ , Hao-Jie Ma ₁ , Yi Yang ₁ , Yan Jiang ₁

Affiliation

MgI₂-catalyzed nucleophilic ring-opening reactions of donor–acceptor cyclopropanes with indoline-2-thiones as easy-to-handle sulfur nucleophiles were investigated. A series of functionalized γ-indolylthio butyric acid derivatives were synthesized in good to excellent yields under mild reaction conditions. Furthermore, the thioether functionalized ring-opening products could be transformed to sulfone and methionine analogues.

中文翻译：

MgI2催化供体-受体环丙烷与二氢吲哚-2-硫酮的亲核开环反应

研究了MgI ₂催化的供体-受体环丙烷与作为易于处理的硫亲核试剂的二氢吲哚-2-硫酮的亲核开环反应。在温和的反应条件下以良好至优异的收率合成了一系列官能化的γ-吲哚硫代丁酸衍生物。此外，硫醚功能化的开环产物可以转化为砜和蛋氨酸类似物。

更新日期：2022-08-02

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